A modular designed copolymer with anti-thrombotic activity and imaging capability.
نویسندگان
چکیده
Through a modular ROMP (ring-opening metathesis polymerization) strategy, a random copolymer with anti-thrombotic activity and imaging capability has been constructed from RGD, rhodamine B and PEG modified norbornene monomers. As we expected, these tri-component polynorbornenes exhibit significant enhancement in anti-thrombotic efficacy and bioavailability in vivo.
منابع مشابه
Evaluation of radiolabeled streptokinase for thrombosis imaging
Introduction: Cardiovascular disease is the major cause of morbidity and mortality in developing and developed countries. Rapid diagnosis of the thrombosis can be an essential step in management of the stroke. Methods: In this work a recently developed radiolabeled streptokinase (STP) tracer was evaluated in an animal thrombotic model using SPECT imaging and biodis...
متن کاملSuccessful Treatment of Refractory Thrombotic Thrombocytopenic Purpura with Rituximab, a Monoclonal Antibody: a Case Report
Thrombotic thrombocytopenic purpura (TTP) is mostly attributed to the presence of an autoantibody against ADAMTS-13, a metalloprotease that degrades ultralarge von Willebrand protein multimers. Accumulation of vWF multimers and systemic platelet aggregation lead to microangiopathic thrombosis, hemolytic anemia, and end-organ ischemia. Most patients respond to therapeutic plasma exchange (TPE), ...
متن کاملInvestigation the status of instructional design with modular method in medical education
Background and Goal: Modular method is a form of in-service training which provides job skills into a form of independent training of audiences. Each of modular provides specific skill and at the same time besides the other modular led to a new and comprehensive skill. In fact, any educational modular is a set of knowledge, attitudes and skills which by using them it can be possible to do ...
متن کاملEnhancing AUV Operational Capabilities: Hovering,
This proposal describes a program of work designed to contribute to the Navy's capabilities in mastering the mine warfare problem by providing AUV hovering, rendezvous, and docking capability in modular reconfigurable AUVs. These enhanced maneuvering capabilities will extending mission durations, enable stormy weather operations, and provide station keeping abilities for imaging and interventio...
متن کاملشدت وازوموتور راکتیویتی عروق مغزی در ترومبوز سینوسهای وریدی مغزی ومقایسه آن با وازو راکتیویتی نرمال با استفاده از داپلر ترانس کرانیال
Background and Aim: Thrombosis of the cerebral veins and sinuses is a distinct cerebrovascular disorder that most often affects young adults and children. Failure in brain autonomic activity could be provoked because of damage to energy-dependent cellular membrane pumps resulting from cytotoxic edema and cerebral ischemia. Measurement of vasomotor reactivity (VMR) through Trans-cranial Dopp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Chemical communications
دوره 50 67 شماره
صفحات -
تاریخ انتشار 2014